Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives.
Kniewald Z; Zechner V; Kniewald J
Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia.
Endocr Regul, 26(1):47-51 1992 Mar
The metabolism of testosterone in the rat ventral prostate, anterior pituitary, basal
hypothalamus and amygdala was studied in vitro under the influence of vitamin B6
compounds. The influence of these compounds on the activity of 5 alpha-reductase (5
alpha-R), 3 alpha- and 17 beta-hydroxysteroid dehydrogenase (3 alpha-HSD, 17 beta-HSD) was
determined for all the examined tissues. Pyridoxine hydrochloride
significantly increased the activity of 5 alpha-R, 3 alpha- and 17 beta-HSD, but pyridoxal
hydrochloride had an inhibitory influence on 5 alpha-R and showed no effect on 3 alpha-HSD
activity at the prostate level. Male rat anterior pituitary, basal hypothalamus or
amygdala incubated with pyridoxal phosphate and pyridoxal hydrochloride showed modified
enzymatic activities. Pyridoxal hydrochloride showed an inhibitory effect on 5 alpha-R in
the rat pituitary and basal hypothalamus as well as in the rat prostate.
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