Larue JP; Morfin RF; Charles JF
J Urol (Paris) 1985; 91 (7): 463-8
LANGUAGE OF ORIGIN
The quantities of zinc naturally present in prostatic epithelial cells
determine the human prostate to be a zinc-rich gland. Since the growth
of the prostate depends on androgenic steroid hormones, interrelationships
between steroids and zinc were investigated. It appears now that zinc in
hyperplastic prostates is bound to cytoplasmic citrate. Metabolic homeostasia
in prostatic secretory cells may be insured by inhibition of cis-aconitase
by free zinc and its binding to accumulating citrate. The yields of bound
zinc are decreased by androgenic steroids (testosterone, 5 alpha-dihydrotestosterone,
5 alpha-androstane-3 alpha, 17 beta-diol) which increase in turn the levels
of free zinc, the uptake and the reduction of testosterone and citrate
accumulation. In dedifferentiated hormono-independent neoplastic cells,
there is less reduction of testosterone and a drastic decrease in zinc
levels due to the sole presence of a metallothionein for binding. (AUTHOR)
MJTR: Prostate AN. Zinc AN.
MNTR: Cell Nucleus AN. Cytosol AN. English Abstract. Human. Ligands.
Male. Prostatic Hyperplasia ME. Prostatic Neoplasms AN. Testosterone ME.
Zinc ME. JOURNAL ARTICLE
RNUM: 0 (Ligands); 57-85-2 (Testosterone); 7440-66-6 (Zinc)
IDEN: ISSN: 0248-0018. JOURNAL-CODE: IHD. ENTRY-DATE: 860312. JOURNAL-SUBSET:
M. IM-DATE: 8605.